Document Type : Original Research Article


1 Assistant Professor of Orthopaedics, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2 Associate Professor of Anesthesiology, Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran


Introduction:  Cefazolin injection at home is usually prescribed by specialists in hospital or clinical settings to treat bacterial infections. Cefazolin may be prescribed to people who have a bacterial infection whose body does not respond to other antibiotics or to people who are at risk of infection after surgery.
Material and Methods: The main result was the emergence of any SSI within a year of surgery. The surgical information recording system had records for every patient who underwent THA. The attending surgeon examined the surgical site daily while the patient was admitted, and the clinical data was documented on a standardized record form. Patients were scheduled for follow-up appointments in the outpatient clinic at 2 & 6 weeks, 3 & 6 months, and 1 year after surgery following discharge.
Results: Simple dressings, superficial wound revision, and short-term oral antibiotics were used to treat cases of superficial incisional SSIs. Deep incisional and organ-space SSI cases underwent open or arthroscopic debridement while keeping the prosthesis in place, either with or without subsequent oral medications.
Conclusion:  In case of infection in the artificial joint, the most important point is timely diagnosis. Symptoms can be swelling, redness and pain in the affected joint. It is important not to start antibiotics for the patient before a definitive diagnosis because it not only makes the diagnosis difficult, but also interferes with proper and effective treatment. For diagnosis, it is necessary, if necessary, draw joint fluid and send it to the laboratory. In cases where the infection was detected in time in the first four weeks from the beginning, the treatment can be done by keeping the prosthesis. In these cases, washing the joint completely and prescribing appropriate antibiotics based on culture results controls the infection in 80% of cases.

Graphical Abstract

Investigating the Effectiveness of Prophylactic Cefazolin Injection before Spinal Anesthesia on Hemodynamic and Clinical Symptoms of Infection in Total Hip Arthroplasty


Main Subjects

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Mohammad Irajia , Hassan Mohammadipour Anvari. Investigating the Effectiveness of Prophylactic Cefazolin Injection before Spinal Anesthesia on Hemodynamic and Clinical Symptoms of Infection in Total Hip Arthroplasty ‏‏‏, Ad. J. Chem. B, 5 (2023) 344-356.
DOI: 10.48309/ajcb.2023.408529.1179