Document Type : Review Article


1 Assistant Professor of Anesthesiology, Department of Anesthesiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2 Assistant Professor of Orthopaedics, Department of Orthopedics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


ntroduction: Due to the fact that orthopedic surgeries have increased a lot in recent years and some of these patients undergo surgery under G/anesthesia, the shivering possibility after surgery has increased in them. Therefore, it is necessary to take preventive measures; this study was conducted as a systematic review to investigate the safety and effectiveness of two drugs, ondanestreon and meperidine, in preventing shivering after anesthesia in patients who are candidates for orthopedic surgeries.
Methodology: This research is a systematic review based on the PRIZMA guidelines in 2022 by searching the keywords ondansetron, meperidine, prevention, chills, orthopedics, and general anesthesia in all databases that publish medical articles without restrictions.
Results: The average number of minutes of zero shivering score in all patients who were fully treated before the 10th minute in the two groups was in the 7th minute and earlier in the meperidine group than in the ondansetron group and was significantly different. 29% in the ondansetron group and 31% in the meperidine group did not reach zero score at the 10th minute, and there was a need to re-inject the drug to control shivering.
Conclusion: Although ondansetron is effective in the shivering treatment after general anesthesia, its strength and speed are weaker compared to meperidine. Therefore, the results of this study could not prove that ondansetron has different efficacy and safety compared to ondansetron or vice versa.

Graphical Abstract

Safety and Efficacy of Two Drugs, Ondansetreon and Meperidine, in Preventing Shivering after Anesthesia in Orthopedic Surgery Candidates: A Systematic Review Study


Main Subjects

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