@article { author = {Zargar, Noor and Zaman Khan, Khaliq uz}, title = {Mechanistic Investigation of Formation of Some Pharmacological Active Beta-Diketo Compounds and Related Nitrogen Heterocycles}, journal = {Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry}, volume = {3}, number = {2}, pages = {160-175}, year = {2021}, publisher = {Sami Publishing Company}, issn = {2716-9634}, eissn = {2716-9634}, doi = {10.22034/ajcb.2021.258161.1070}, abstract = {Beta-diketo compounds and related N-heterocycles have played a significant role in synthetic organic chemistry. A multistep mechanism for a catalyze base reaction of 1,3-indandione 1 with acetone has been developed to afford a complex molecule, 3-(1,3-Dioxo-2-indanylidene)-1,1-dimethyl-1,2,3,4,4d, 9a-hexahydrofluorene 2. Pharmacologically active compounds 3, with anticoagulant and antispasmodic properties, have been synthesized through the reaction of 2-substituted 1,3-indandione with β-chloro-vinyl ketones. Interaction of phthalimide 4 with benzyl chloride in DMF in presence of K2CO3-Al2O3 leads to the formation of N-benzyl phthalimide 11.N-substituted products of type 15 and 16 have been obtained when 6-alkyl or aryl -4(aryl methyl) pyridazine-3(2H)-ones 14 interacted with Bromo-ethyl acetate and acetic-anhydride respectively. However, 3-chloro substituted pyridazines 17 afforded 3-mercaptopyridazine derivatives 18 when interacted with thiourea.In this paper, we suggest multistep mechanisms for a series of compounds and all the proposed mechanisms are unknown.}, keywords = {benzylation,Pyridazine,acetic-anhydride,bromoethylacetate,Thiourea,mercaptopyridazine}, url = {https://www.ajchem-b.com/article_130209.html}, eprint = {https://www.ajchem-b.com/article_130209_970456b9438b68f071534b6e53872b04.pdf} }