Document Type : Review Article


1 College of Pharmacy,Yonsei University, Yeonsu-gu,Incheon, Republic of Korea

2 College of Pharmacy, Gachon University, Yeonsu–gu,Incheon, Republic of Korea



This review aims to provide overall aspects of the history, biology, chemistry and the total synthesis of Aflavinines.  The origin of this molecule traced back from the isolation and structural elucidation by Clardy and co–workers in 1980 [Tetrahed. Lett. 1980;21:243–246]. Most of the previously published total syntheses were covered in a brief summary and the key points of each work are highlighted. Moreover, various antiinsectant and antiviral Aflavinines congener are presented. This review is almost the first in Aflavinine topics covering all aspects in brief, to the best of our knowledge.

Graphical Abstract

Aflavinines: History, Biology and Total Synthesis