Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
Synthesis, crystal structure, Hirshfeld surface, crystal voids, energy frameworks, DFT and molecular docking analysis of (2,6-dimethoxyphenyl)acetic acid
1
16
EN
Ruchika
Sharma
Chemical Crystallography Laboratory, Department of Physics, University of Jammu, Jammu Tawi-180006, India.
ruchi18nik@gmail.com
Mulveer
Singh
Chemical Crystallography Laboratory, Department of Physics, University of Jammu, Jammu Tawi-180006, India.
mulveer@gmail.com
Kamal
K
Department of Chemistry, Indian Institute of Technology, Jammu, 181221, India.
2018rcy0006@iitjammu.ac.in
Nitin
G
Ghatpande
Department of pharmaceutical Chemistry, School of Health Science, University of KwaZulu- Natal, Durban-4041, South Africa.
nitin@rosslife.net
Mahidansha
M
Shaikh
Department of pharmaceutical Chemistry, School of Health Science, University of KwaZulu- Natal, Durban-4041, South Africa.
shaiksm@ukzn.ac.za
Jagannath
S
Jadhav
Department of Chemistry, Shivaji University, Kolhapur-416004, M.S., India.
jadhavjs97@rediffmail.com
Saminathan
Murugavel
Department of Physics, Thanthai Periyar Government Institute of Technology, Vellore-632002, Tamil Nadu, India.
smurugavel27@gmail.com
Rajni
Kant
0000-0001-8043-2329
Chemical Crystallography Laboratory, Department of Physics, University of Jammu, Jammu Tawi-180006, India.
rkant.ju@gmail.com
10.22034/ajcb.2022.320258.1102
(2,6-dimethoxyphenyl)acetic acid exists in the triclinic crystal system having space group P-1 and lattice dimensions = 7.66(4) Å, b = 8.16(4) Å, c = 8.65(3) Å, V = 503(4) Å<sup>3</sup> and Z = 2. The molecular and crystal structure was elucidated using X-ray crystallographic techniques. The refinement of all the structural parameters was done using the full-matrix least-squares method and it yielded the final R-factor as 0.0579 for 1711 observed reflections. In the crystal packing, molecules are consolidated by intermolecular O-H....O and intramolecular C-H....O interactions. The O-H….O interaction makes a dimer corresponding to R<sub>2</sub><sup>2 </sup>(8) graph-set motif. Hirshfeld surface (HS) analysis has been complemented to envisage the conformity of the molecular structure. The void-volume analysis has been made to obtain the mechanical strength of the crystal structure. The energy frameworks have been constructed to know the stability of the structure and the kind of dominant energy present in it. The optimized structure using density functional theory (DFT), HOMO–LUMO energy and the charge on the atoms has been examined using B3LYP method. The inhibitory activity of (2,6-dimethoxyphenyl)acetic acid against microbial targets has been assessed using the docking process.
Diffraction,DFT,Organic synthesis,Natural products,pharmaceutical applications
https://www.ajchem-b.com/article_145346.html
https://www.ajchem-b.com/article_145346_5b07436cf2bc70ed96958912521bc246.pdf
Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
Strychnos innocua (Delile): Phytochemical and Antimicrobial Evaluations of its root bark extracts
17
28
EN
Muhammad
Sani Sallau
Department of Chemistry, Ahmadu Bello University, Zaria – Nigeria
jibuttu@gmail.com
Jibrin
Uttu
Ahmed
0000-0002-4089-5529
2Department of Chemistry, Federal University Gashua, Yobe State, Nigeria
jibuttu@yahoo.com
Ogunkemi
Risikat Agbeke
Iyun
Department of Chemistry, Ahmadu Bello University, Zaria – Nigeria
jibuttu1@gmail.com
Hamisu
Ibrahim
Department of Chemistry, Ahmadu Bello University, Zaria – Nigeria
p16psch9029@abu.edu.ng
10.22034/ajcb.2022.323148.1104
The antifungal and antibacterial effects of medicinal plants have long been known. The root bark decoction of <em>Strychnos innocua</em> (a <em>Loganiaceae</em> plant) has been used to treat skin infections, candidiasis, and other disorders. Hence, the aim of this study is to determine the phytochemical, antibacterial, and antifungal properties of root bark extracts of <em>S</em>. <em>innocua</em>. This is the first time a study of this nature is been conducted using the root bark of the plant. Maceration with n-hexane, ethyl acetate, and methanol as solvents was used in the extraction process, while the phytochemical analysis of the extracts followed a standard procedure. This confirmed the presence of flavonoids, coumarines, triterpenes, steroids, saponins, tannins, phenols, anthraquinones, quinones, carbohydrates, phlobatannins, glycosides, cardiac and alkaloids. The extracts exhibited antimicrobial activities against MRSA, <em>B</em>. <em>subtilis</em>, <em>P</em>. <em>aeruginosa</em>, <em>S</em>. <em>aureus</em>, <em>C</em>. <em>krusei</em>, <em>A</em>. <em>fumigatus</em>, <em>C</em>. <em>albicans </em>while no activity against <em>E</em>.<em> coli</em>, <em>S</em>. <em>pyogenes</em>, <em>S</em>. <em>typhii</em>, <em>A</em>. <em>niger</em> and <em>K</em>. <em>Pneumoniae </em>were observed. MIC and MBC/MFC were also determined. In conclusion, the root bark of <em>S. innocua</em> is thought to be rich in phytochemicals and has antifungal and antibacterial effects against some of the tested pathogens.
Phytochemical,MIC,Strychnos innocua,Loganiaceae,Antifungal,antibacterial
https://www.ajchem-b.com/article_145517.html
https://www.ajchem-b.com/article_145517_f63eaa7da4be27899e6cc29f43d607c7.pdf
Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
Phytochemical Screening and the Effect of Methanolic Leaves Extract of Senna mimosoides on Inflammatory Stimulus-Induced Leukocyte Mobilization (In-vivo)
29
38
EN
Abdulrazaq
Tukur
0000-0002-1140-8453
Department of Chemistry, Al-Qalam University, Katsina, Katsina State Nigeria.
abdulrazaqtukur@gmail.com
Nasiru
Malan
Musa
Department of Chemistry, Al-Qalam University, Katsina, Katsina State Nigeria.
birnintsaba@yahoo.com
Jimoh
Tajuddeen
Abdullahi
Department of Chemistry, Al-Qalam University, Katsina, Katsina State Nigeria.
jimohu2332@yahoo.com
James
D
Habila
Department of Chemistry, Ahmadu Bello University, Zaria, Kaduna State Nigeria.
habila1234@yahoo.com
Martha
Bamidele Omotola
Department of Chemistry, Ahmadu Bello University, Zaria, Kaduna State Nigeria.
martha3456@gmail.com
10.22034/ajcb.2022.323175.1105
In traditional medicine, the leaves of <em>Senna mimosoides</em>, has been used to cure oedema and breastfeeding poisoning in newborns. The animal model experiment included a total of twenty-five (25) Wistar albino rats of both sexes, with A (control) receiving 0.2 ml of normal saline. B, C and D received 100, 250 and 500 mg/kg of the methanolic extract respectively, and E receiving 25 mk/kg of the indomethacin standard drug. Preliminary phytochemical screening of the <em>Senna mimisoides</em> methanolic leaves extract indicated the presence of ten (10) different secondary metabolites, including; carbohydrates, glycosides, tannins, reducing sugars, phenols, steroids, terpenoids, saponins, alkaloids and flavonoids. When compared to the control, the total leukocyte count of the groups treated with various dosages of extracts increased in a dose-dependent manner, whereas the group treated with indomethacin fell dramatically. The extract dramatically increased leukocyte mobilization, according to the findings. The results of this investigation showed that the methanolic leaves extract of <em>Senna mimosoides</em> contains medically relevant bioactive components, indicating that it can be used in traditional medicine to treat ailments. The anti-inflammatory property of the extract is not at the level of leuckocyte mobilization. According to this study, however, the extract’s ability to stimulate leukocytes implies that it may have a function in immunological response.
Senna mimosoides,anti-inflammatory,leukocytes mobilization,Methanolic extract,phytochemistry
https://www.ajchem-b.com/article_146039.html
https://www.ajchem-b.com/article_146039_9e8ee29071ae4f62761b90cbdf1d8031.pdf
Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
Green synthesis of Copper Nanoparticles and Investigation of its Antimicrobial Properties
39
52
EN
Ifeoluwa
Israel
Alao
Department of Chemistry, Federal University of Technology, Akure, Nigeria
alaoifeoluwa@gmail.com
Ifeoluwa
Peter
Oyekunle
0000-0001-7623-4493
Department of Chemistry, Federal University of Technology, Akure, Nigeria
ifeoluwapeter@gmail.com
Kingsley
O
Iwuozor
0000-0002-1161-2147
Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria
kingsleyiwuozor5@gmail.com
Ebuka
Chizitere
Emenike
0000-0001-7117-3265
Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University, Awka, Nigeria
emenikechizitere@gmail.com
10.22034/ajcb.2022.323779.1106
Nanoparticles containing copper metal ions and their derivatives are being used for different medical purposes to prevent infections, ulcers etc. The aim of this study was to qualitatively determine the phytochemicals present in the ethanolic extract of <em>Kigelia africana</em> fruit (which are responsible for the reduction of the copper ions as well as stabilization of the nanoparticles), the synthesis of copper nanoparticles (CuNPs) through a green synthesis route from the ethanolic extract of <em>Kigelia africana</em> fruit and the anti-microbial assessment of the synthesized CuNPs. The synthesized nanoparticles were characterized by UV-Vis Spectrophotometer. Phytochemical screening revealed the presence of alkaloids, glycosides, flavonoids, phenols, steroids, tannins, carbohydrate and terpenoids. The synthesized CuNPs were confirmed by the change in colour from dark yellow to dark green. The CuNPs displayed promising antibacterial activity on <em>Pseudomonas aeruginosa, Shigella sp., Staphylococcus aureus,</em> <em>Salmonella typhi, E. coli</em>. The highest inhibition activity was exhibited by <em>Pseudomonas aeruginosa</em> (17.0 ± 4.24 mm). The CuNPs showed considerable antifungal activity against <em>Aspergillus flavus</em> and <em>Aspergillus niger </em>with inhibition activity of 8.0 ± 2.83 mm and 3.0 ± 4.24 mm respectively. Conclusively, the synthesized CuNPs from <em>Kigelia africana</em> should be incorporated as a therapeutic drug for microbial infectious disease and other health associated disorders.
Green synthesis,Copper nanoparticles,Anti-bacteria,Anti-fungi,Kigelia africana
https://www.ajchem-b.com/article_146047.html
https://www.ajchem-b.com/article_146047_ab9af24d4b4412938845f75fac0d2e9c.pdf
Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
investigation of physicochemical and fatty acid composition of oils from ripe and unripe blighia sapida fruit
53
61
EN
Bashir
Oladapo
Olaniyi
0000-0002-1360-8846
Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin Nigeria.
olaniyibashir02@gmail.com
Omolara
Olusola
Oluwaniyi
Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin Nigeria.
oluwaniyi@unilorin.edu.ng
Ibrahim
Opeyemi
Oloruntele
Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin Nigeria.
olorunteleibrahim@gmail.com
Hauwa
Adenike
Sekoni
Department of Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin, Ilorin Nigeria.
hauwasekoni@gmail.com
10.22034/ajcb.2022.330991.1110
<em>Blighia</em> <em>sapida</em>, commonly known as ackee, is an inherent tree crop of West Africa which is prevalent in tropical and subtropical environments. Various parts of the ackee tree are employed in traditional medicine for treatment of several ailments. However, limited information exists on the health benefits and composition of the fruit oils, thus the need for scientific knowledge of the composition, nutritional, antioxidant, physicochemical parameters, and the other properties of the fruit oils for its efficient utilization/ developmental purposes. Physicochemical properties and fatty acid composition of oils from the arils and seeds of ripe and unripe <em>Blighia sapida</em> (ackee) were quantified using standard analytical techniques. The specific gravity of the seed oils ranged between 0.85 - 0.88; saponification value of the oil of the ripe arils (146.74 ± 0.71) was much higher than those of the other oils under investigation, while the oil of the unripe seed had the lowest saponification value (76.10 ± 2.32). The ripe aril oil had the lowest acid value of 11.20 ± 4.65 mg/g, and ripe seed oil recorded the highest acid value of 42.09 ± 0.01 mg/g. The other parameters investigated include the ester value, iodine value, peroxide value, and the % Free Fatty Acid. The fatty acid composition of the oil of the ripe aril are arachidic acid (4.9%), gondoic acid (7.76%), oleic acid (31.76%), palmitic acid (49.20%), palmitoleic acid (1.28%), and stearic acid (5.00%); while arachidic acid (8,58%), behenic acid (36.28%), oleic acid (8.75%), palmitic acid (36.05%), and stearic acid (10.34%) are the fatty acids present in the unripe aril oil. This study concludes that ackee oils may find usage as industrial oil.<strong> </strong>The results confirmed ackee fruit to be a moderately oily fruit that can be exploited, with proper refining, to produce edible oil, soap, cosmetics, and the other industrial products.
Blighia Sapida,Physicochemical Parameters,Fatty Acid,Oil
https://www.ajchem-b.com/article_148288.html
https://www.ajchem-b.com/article_148288_31dc7dd47831f2c1c6af99e2d57ab755.pdf
Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
Investigation of Standard Natural Gas Synthesis Technologies
62
74
EN
Masood
Bagheri Sadr
Centre for Sustainable Infrastructure, Department of Civil and Construction Engineering, Swinburne University of Technology, Melbourne, Australia
masoudbagherisadr.1983@gmail.com
kIM
LO HAN
Department of Chemical Engineering, Seoul University, Korea
kim.lo.1975.korea@gmail.com
10.22034/ajcb.2022.332311.1111
Natural gas is often associated with oil and pushes oil out of the soil into extraction wells. As the oil-gas mixture rises in the wells, gas is released and carries the mixture to the top of the well. In oils which are not saturated with gas and are only under water pressure, the amount of dissolved gas is less and in supersaturated oils, the amount of gas is higher. There are also streams which contain only natural gas and no oil. The term synthetic gas refers to the gas mixtures which contain Co and H<sub>2</sub> in different proportions. H<sub>2</sub> and Co are two important substances in the chemical industry and have many uses. Co is used in the production of paints, plastics, foams, insecticides, herbicides, acids, etc., including the use of hydrogen, ammonia production, hydrogenation, and hydrocracking. Synthesis gas is a very valuable raw material for the production of various chemical substances. Using this gas and various processes, it is possible to produce many different chemical substances which depending on the production method, different ratios of hydrogen to Co are obtained. Likewise in industrial use, different ratios are required depending on the process in which the gas is used. Synthetic gas feeds can be hydrocarbons, coal, oil, natural gas, and then vegetable and animal products.
Natural gas,Synthesis,Chemical industry,Hydrocracking,Hydrogenation
https://www.ajchem-b.com/article_148313.html
https://www.ajchem-b.com/article_148313_4d4e78c7771e77abbbd79f61d7ec719b.pdf
Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
A brief overview of the preparation and application of additives in lubricating oils in industry
75
91
EN
kIM
LO HAN
Department of Chemical Engineering, Seoul University, Korea
kim.lo.1975.korea@gmail.com
Masood
Bagheri Sadr
Centre for Sustainable Infrastructure, Department of Civil and Construction Engineering, Swinburne University of Technology, Melbourne, Australia
masoudbagherisadr.1983@gmail.com
10.22034/ajcb.2022.332314.1112
Mineral lubricants derived from crude oil are relatively inexpensive products used in very expensive engines and industrial machinery and have a direct impact on the efficiency and life of these devices, so it must be ensured to ensure the correct operation of machinery. The quality of oils used is quite good, but unfortunately it has been seen that this important issue is not paid enough attention even by technical experts and in our country much less than it should be valued the quality of oil and how to control it. Petroleum products are the most complex in terms of the relationship between physical and chemical properties and practical efficiency. We know that the type and ratio of different compounds that exist in crude oil in different parts of the world, a country or a region, is very variable. Even in an oil well, especially at different depths, there are different types and percentages of chemicals in crude oil. Petroleum lubricating oils therefore contain a wide variety of hydrocarbons and their derivatives, especially as the components of lubricating oils are generally composed of very large molecules (C15 to C30).
Oils,Petroleum Products,Physical and Chemical Properties of Lubricants
https://www.ajchem-b.com/article_148316.html
https://www.ajchem-b.com/article_148316_776b03a2e182f986ec5e1e7d54572c1c.pdf
Sami Publishing Company
Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry
2716-9634
4
1
2022
03
01
Chemical Evaluation of the Effects of Analgesics on the Body's Chemical Cells
92
103
EN
Martin
Alphin
0000-0002-1176-2436
Department of Research and Development, UOP, Vian, Austria
mrtnalphin@gmail.com
10.22034/ajcb.2022.333534.1114
Pain is a sensory state and indicates a disorder in the body. It can be affected in two ways. First, the sensitivity of the relevant receptors can be reduced to such an extent that their excitability is reduced or eliminated by pain waves, which results in a reduction or disappearance of the sensation of pain. It is also possible to induce analgesia by attenuating or eliminating pain waves which enter the thalamus and affect sensitive cortices in the brain. With the synthesis and discovery of new analgesics, the classification of analgesics into non-narcotic compounds and other narcotic compounds is no longer common, and today they are divided into two main groups in terms of potency: weak analgesics and strong analgesics. The first group consists of compounds which are suitable for the treatment of simple and moderate pain and most of them have antipyretic, anti-inflammatory (anti-inflammatory), and anti-rheumatic effects. Very severe pain such as pain from surgery, cancer pain, renal colic, and biliary cannot be relieved with the first group of compounds, and for this, strong analgesics are used which are mostly drugs.
Antipyretic,Antiphlogistic,Environment,Non-Narcotic,Anti-Rheumatic
https://www.ajchem-b.com/article_148327.html
https://www.ajchem-b.com/article_148327_8a5060f0fea85cd382e276937010b5f9.pdf