%0 Journal Article %T Green and Efficient Synthesis of Baclofen %J Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry %I Sami Publishing Company %Z 2716-9634 %A Fernandes, Pearl Rhea %A Madnala, Ashwini . %A Donde, Nisha . %A Pawar, Amit Anil %A Sonawale, Maryappa C. %D 2022 %\ 04/01/2022 %V 4 %N 2 %P 158-163 %! Green and Efficient Synthesis of Baclofen %K GABA agonist %K 4-Chlorobenzaldehyde %K Cyanohydrin %K Oxidizingagent %K Pyridinium %K Wittig type reaction. Hydrolysis %K reduction %R 10.22034/ajcb.2022.342298.1120 %X Baclofen is a Gamma Amino Butyric acid (GABA) agonist to relax skeletal muscles. It is especially effective in treating muscular spasticity. In this research, we now describe the synthesis of Baclofen using a new approach which begins with 4- chlorobenzaldehyde. We have carried all reactions by the green method. It gives the better yield.  The identity of this product was confirmed by spectral analysis and compared with the standard Baclofen. New and eco-friendly approach was developed for the synthesis %U https://www.ajchem-b.com/article_152263_0279adf05d994f89dc3dbd1a235cdd51.pdf